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Author(s)
B. C. Foster
C. E. Drouin
K.D. Gallicano
J. Livesey
J. T. Arnason
E. Mills
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Abstract:
Milk thistle (Silybum marianum) has been used since antiquity as a medicinal herb. Recent studies have found that some herbal products used concomitantly with conventional therapeutic products can markedly affect drug disposition. The in vitro effect of aliquots from 5 commercially available single-entity and blended products containing milk thistle on cytochrome P450 2C19, 3A4, 3A5 and 3A7-mediated metabolism has been determined with aqueous and ethanolic extracts. Total and constituent silymarin analysis found similarities in the amounts of the various constituents detected. Analysis of total silibin A + B revealed that there are marked differences in the products tested. Milk thistle extracts from the products tested exhibited a marked capacity to inhibit cytochrome P450-mediated metabolism.
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